2 edition of Regulation and action of nitric oxide synthase in insulin-secreting cells found in the catalog.
Regulation and action of nitric oxide synthase in insulin-secreting cells
Veronique Damienne Belin
Written in English
D.Phil. 2001. BLL DXN037487.
|Statement||by Veronique Damienne Belin.|
|Series||Sussex theses ; S 4955|
Carnosine acts on multiple targets within cells and tissues to quench the chemical reactions that prevent proteins from functioning properly. 22,24,25 One benefit discovered early from this process is a suppression of elevated blood pressure in diabetic animals. 22 An animal study showed that carnosine decreases blood glucose levels indirectly through beneficial effects on the autonomic. The cytokine IL-1 5 inhibits insulin release and is selectively cytotoxic to beta-cells in isolated pancreatic rat islets. IL-1 5 induces nitric oxide (NO) via the enzyme inducible nitric oxide synthase (iNOS) and NO seems to be a major effector molecule in IL-1 5-induced beta-cell damage/5.
Essential Role for Membrane Lipid Rafts in Interleukin-1 -Induced Nitric Oxide Release From Insulin-Secreting Cells: Potential Regulation by Caveolin-1+ 25 August | Diabetes, Vol. 54, No. 9 Myristic Acid Stimulates Endothelial Nitric-oxide Synthase in a CD and an AMP Kinase-dependent Manner. Differentiation dependent effects of IL‐1 and TGF‐β on human articular chondrocyte proliferation are related to nitric oxide synthase expression. J. Mechanisms for the coordination of intercellular calcium signaling in insulin‐secreting cells. J. Cell Sci. A system for studying the regulation .
The lateral hypothalamus(LH), also called the lateral hypothalamic area, contains the primary orexinergic nucleus within the hypothalamus that widely projects throughout the nervous system; this system of neurons mediates an array of cognitive and physical processes, such as promoting feeding behavior and arousal, reducing pain perception, and regulating body temperature, digestive functions MeSH: D » Publications; Publications. Search. Show only items where. Author Human vascular tissue models formed from human induced pluripotent stem cell derived endothelial cells.. Stem Cell Rev. 11(3) Niu Y, Bai J, Kamm RD, Wang Y, Wang C.
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Insulin secretion from pancreatic β-cells is triggered by a rise in the cellular glucose concentration. This glucose dependency of secretion is largely due to limitations placed on glycolysis by glucokinase (GCK) (1, 2), which has a low binding affinity for glucose and half-maximal activity at approximately 8 m glucose concentrations less than about 5 m m, metabolic flux through Cited by: 8.
Due to their low molecular weights, the cytokines penetrate into the capsules and directly induce necrosis or apoptosis of the cells. It has been widely accepted that the cytokines stimulate nitric oxide synthase expression levels of immune cells and insulin secreting cells, which cause severe malfunction and death of encapsulated cells.Cited by: Request PDF | Epigenetics and the Regulation of Nitric Oxide | Epigenetic modifications to chromatin alter the accessibility of DNA to nuclear factors.
These modifications can involve DNA. Insulin-dependent diabetes mellitus is characterized by selective destruction of insulin-secreting cells found in pancreatic islets.
Cytokines, derived from activated macrophages and lymphocytes, are believed to participate in cell damage by stimulating inducible nitric oxide synthase (iNOS) expression and nitric oxide production in islets.
Protection of insulin secreting cells from nitric oxide induced cellular damage by crosslinked hemoglobin. Chae SY(1), Lee M, Kim SW, Bae YH. Author information: (1)Department of Materials Science and Engineering, Kwangju Institute of Science and Technology, Cited by: Nitric Oxide, Cell Signaling, and Gene Expression is the first comprehensive work to showcase the highly useful diversity of cellular effects elicited by nitric oxide.
A collection of expert contributors provides cutting-edge information on a variety of topics with tremendous Author: Santiago Lamas. Interleukin-1 beta (IL-1 beta) is a potent stimulant of inducible nitric oxide synthase (iNOS) mRNA and nitric oxide (NO) production in vascular smooth muscle (VSM) cells in : Daniela Salvemini.
Protection of insulin secreting cells from nitric oxide induced cellular damage by crosslinked hemoglobin. [Su Young Chae, Minhyung Lee, Sung Wan Kim, You Han Bae] PMID Abstract Pancreatic islets and insulinoma cells are particularly vulnerable to serious damage by cytotoxic nitric oxide (NO) and/or oxidative stress, most probably.
Regulation of insulin secretion by glucose in pancreatic β cells. • Similar to other neuroendocrine cells, insulin-secreting cells are electrically excitable. • This means that insulin secretion in response to glucose is dependent on initiation of electrical activity. Abstract. Glucocorticoids are steroid hormones that regulate multiple aspects of glucose homeostasis.
Glucocorticoids promote gluconeogenesis in liver, whereas in skeletal muscle and white adipose tissue they decrease glucose uptake and utilization by antagonizing insulin by: Transgenic mice overexpressing type 2 nitric-oxide synthase in pancreatic beta cells develop insulin-dependent diabetes without insulitis.
J Biol Chem. ; Rabinovitch A, Suarez-Pinzon WL, Strynadka K. et al. Human pancreatic islet β-cell destruction by cytokines is independent of NO production.
J Clin Endocrinol Metab. Observations in islet cells have shown that IL-1β-mediated toxicity is partly induced by production of reactive oxygen species, in particular nitric oxide (NO), through the activation of the NF-κB pathway. iNOS gene silencing also protects these cells from inflammatory cytokine-induced apoptosis and increases their capacity to secret insulin Cited by: Abscisic acid ([ABA]) is a well-studied regulator of stomatal movement.
Hydrogen sulfide ([H2S]), a small signaling gas molecule involved in key physiological processes in mammals, has been recently reported as a new component of the [ABA] signaling network in stomatal guard cells.
In Arabidopsis (Arabidopsis thaliana), [H2S] is enzymatically produced in the cytosol through the. Oxidative Stress, Nitric Oxide, and Diabetes. Dario Pitocco 1, 2, Francesco Zaccardi 1, 2, Enrico Di Stasio 3, Federica Romitelli 3, Stefano A.
Santini 3, Cecilia Zuppi 3, Giovanni Ghirlanda 1. 1 Institute of Internal Medicine, Catholic University of Rome, Largo Agostino Gemelli 8, Rome, Italy 2 Contributed equally to the article 3 Department of Biochemistry, Catholic University of Rome. The inhibitory action of leptin has been well known in clonal β Accumulation of FoxO1 in the nucleus of insulin-secreting cells is triggered by palmitate during induction of in isolated human lipotoxic islets with a reduction in intra-islet triglyceride accumulation and reduced inducible nitric oxide synthase (iNOS Author: Alpana Mukhuty, Chandrani Fouzder, Snehasis Das, Dipanjan Chattopadhyay.
Nitric oxide (NO) and hydrogen sulfide (H 2 S) have been reported to close the stomata in different plant species, and the production, mode of action, and interplay between them and with other molecules are under constant by: 5. There is an extensive literature on the β-cell cytotoxic effects of free oxygen and nitric oxide radicals elaborated either by infiltrating immune cells or as a result of cytokine-induced β-cell specific expression of enzymes generating these radicals (inducible nitric oxide synthase).
Figure However, pretreatment of L-NAME (5 mg/kg, ip), nitric oxide synthase inhibitor caused a potentiation in the protective effect of Curcumin (P. Dicarbonyl stress occurs when dicarbonyl metabolites (i.e., methylglyoxal, glyoxal and 3-deoxyglucosone) accumulate as a consequence of their increased production and/or decreased detoxification.
This toxic condition has been associated with metabolic and age-related diseases, both of which are characterized by a pro-inflammatory and pro-oxidant state. Methylglyoxal (MGO) is the most reactive Cited by: 7. Blood glucose regulation by pancreas. The major cause of type 1 diabetes is loss of insulin-secreting pancreatic β cell and insulin inadequacy (3;4).
For a better understanding of the pathogenesis of type 1 diabetes, the regulatory mechanisms of blood glucose by pancreaswill briefly by: 2. Thus, 24 hours of in vitro treatment with EV MP from MetS patients, but not that from healthy subjects, inhibits endothelial nitric oxide synthase, resulting in a reduction of nitric oxide production by endothelial cells.
66 This is associated with an increase of peroxynitrite formation without modification of proinflammatory cytokine by: Inducible nitric oxide synthase may be upregulated in the presence of proinflammatory cytokines or indeed specific fatty acids, and under these conditions, l-arginine consumption and metabolism may have a negative impact on β-cell function.
Chronically elevated nitric oxide levels will reduce insulin secretion, possibly by interfering in Cited by: Enter search terms. Keep search filters New search. Advanced search.